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Study Results Shows Significantly Higher Response Rates for Taltz (ixekizumab) of Lilly Compared to Stelara (ustekinumab) in Patients with Moderate-to-Severe Plaque Psoriasis

March 4, 2017 Eli Lilly and Company has announced that patients with moderate-to-severe plaque psoriasis treated with Taltz® (ixekizumab) demonstrated superior efficacy at 24 weeks compared to patients treated with Stelara®* (ustekinumab). Detailed results from the IXORA-S study were presented during the American Academy of Dermatology (AAD) Annual Meeting taking place March 3-7 in Orlando, Fla. Kristian Reich, M.D., Ph.D., lead author … Continue reading Study Results Shows Significantly Higher Response Rates for Taltz (ixekizumab) of Lilly Compared to Stelara (ustekinumab) in Patients with Moderate-to-Severe Plaque Psoriasis

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Perjeta regimen of Roche helped people with an aggressive type of early breast cancer live longer, Phase III APHINITY study shows

March 2, 2017 Roche, Breast European Adjuvant Study Team (BrEAST), the Breast International Group (BIG) and Frontier Science Foundation (FS) have announced positive results from the phase III APHINITY study, which met its primary endpoint and showed that adjuvant (after surgery) treatment with the combination of Perjeta® (pertuzumab), Herceptin® (trastuzumab) and chemotherapy (the Perjeta-based regimen) … Continue reading Perjeta regimen of Roche helped people with an aggressive type of early breast cancer live longer, Phase III APHINITY study shows

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Lynparza meets primary endpoint in Phase III trial in BRCA-mutated metastatic breast cancer

17 February 2017 AstraZeneca has announced positive results from its Phase III OLYMPIAD trial comparing Lynparza (olaparib) tablets (300mg twice daily) to physician’s choice of a standard of care chemotherapy in the treatment of patients with HER2-negative metastatic breast cancer harbouring germline BRCA1 or BRCA2 mutations. It was found that patients treated with Lynparza showed a clinically-meaningful and statistically-significant improvement … Continue reading Lynparza meets primary endpoint in Phase III trial in BRCA-mutated metastatic breast cancer

Bayer and J&J wrap positive PhIII cardio study for Xarelto

February 8, 2017 Bayer and its part­ners at J&J, back in the fall of 2012, started a mas­sive study to see if the drug Xarelto (ri­varox­a­ban) could help pre­vent major car­dio­vas­cu­lar events like my­ocar­dial in­farc­tion, stroke, and death in high risk pa­tients with coro­nary artery dis­ease or pe­riph­eral artery dis­ease. Very recently, a lit­tle more … Continue reading Bayer and J&J wrap positive PhIII cardio study for Xarelto

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Amgen Announces the Efficacy of Repatha® (Evolocumab) for Reducing The Risk Of Cardiovascular Events

Feb. 2, 2017 Amgen has announced that the FOURIER (Further Cardiovascular OUtcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk) trial evaluating whether Repatha® (evolocumab) minimizes the risk of cardiovascular events in patients with clinically evident atherosclerotic cardiovascular disease (ASCVD) met its primary composite endpoint (cardiovascular death, non-fatal stroke, non-fatal myocardial infarction (MI), coronary revascularization or hospitalization for unstable angina) and … Continue reading Amgen Announces the Efficacy of Repatha® (Evolocumab) for Reducing The Risk Of Cardiovascular Events

AstraZeneca expands opportunities for 1st-line lung cancer Immuno-Oncology program

17 January 2017 AstraZeneca has provided an update on its Immuno-Oncology (IO) late-stage clinical development program in 1st-line non-small cell lung cancer (NSCLC), including a refinement of the Phase III MYSTIC trial. The MYSTIC trial was initially designed to assess the benefit of durvalumab monotherapy and durvalumab and tremelimumab (durva + treme) combination therapy versus standard-of-care (SoC) … Continue reading AstraZeneca expands opportunities for 1st-line lung cancer Immuno-Oncology program

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Pfizer Announces Positive Top-Line Results from the Comparative REFLECTIONS B538-02 Study for a Potential Biosimilar to Humira (adalimumab), PF-06410293

January 5, 2017 Pfizer Inc. has announced that the confirmatory REFLECTIONS B538-02 study met its primary objective by demonstrating equivalent efficacy as measured by the American College of Rheumatology 20 (ACR20) response rate at Week 12. This trial is evaluating the safety, efficacy, and immunogenicity of PF-06410293 compared to Humira (adalimumab), each taken in combination with methotrexate, in … Continue reading Pfizer Announces Positive Top-Line Results from the Comparative REFLECTIONS B538-02 Study for a Potential Biosimilar to Humira (adalimumab), PF-06410293

Eisai plots new drug applications in US, Europe and China after Lenvima scores in head-to-head liver cancer study

January 25, 2017 Eisai says that its can­cer drug Lenvima (lenva­tinib) hit the pri­mary end­point in a Phase III study for the treatment of liver can­cer, prov­ing non-in­fe­rior to Nex­avar. That suc­cess will set up reg­u­la­tory fil­ings in the US, Eu­rope and Asia, the com­pany adds. Liver can­cer is a par­tic­u­larly big prob­lem in China, where Eisai … Continue reading Eisai plots new drug applications in US, Europe and China after Lenvima scores in head-to-head liver cancer study

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Roche’s emicizumab for the Treatment of haemophilia A meets primary endpoint in phase III study

22 December 2016 Roche has announced that the primary endpoint has been met for the phase III HAVEN 1 study assessing emicizumab prophylaxis in people with haemophilia A and inhibitors to factor VIII. The study revealed a statistically significant reduction in the number of bleeds over time in people treated with emicizumab prophylaxis compared to … Continue reading Roche’s emicizumab for the Treatment of haemophilia A meets primary endpoint in phase III study

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ABOUND Data Explores Safety and Efficacy of ABRAXANE® for the Treatment of Patients with Lung Cancer

Dec 6, 2016 Celgene Corporation has announced interim results from the ABOUND clinical trial program evaluating the use of ABRAXANE® (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) in patients with advanced non-small cell lung cancer (NSCLC). Interim data presented from the ABOUND trials during the IASLC 17th World Conference on Lung Cancer (WCLC) reinforces the benefit of ABRAXANE/carboplatin doublet … Continue reading ABOUND Data Explores Safety and Efficacy of ABRAXANE® for the Treatment of Patients with Lung Cancer